multidrug resistance proteins การใช้

• Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins ( MRPs ).
• "' Small multidrug resistance protein "'is a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds by removing them for the cells.
• Conjugates and their metabolites can be excreted from cells in phase III of their metabolism, with the anionic groups acting as affinity tags for a variety of membrane transporters of the multidrug resistance protein ( MRP ) family.
• The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance protein 4 ( MRP4, ABCC4 ), a member of the ATP-binding cassette transporter superfamily.
• "' PFIC-3 "'is caused by a variety of mutations in ABCB4, the gene encoding multidrug resistance protein 3 ( MDR3 ), which codes for a floppase responsible for phosphatidylcholine translocation.
• These efflux systems include members of the multidrug resistance protein family and the bacterial exchangers Acr3 and ArsB . ArsB can also be a subunit of the ArsAB As ( III )-translocating ATPase, an ATP-driven efflux pump.
• The acetoxymethyl ester of calcein is also used to detect drug interactions with "'multidrug resistance proteins "'( ABC transporters ATP-binding cassette transporter genes ) in intact cells as it is an excellent substrate of the multidrug resistance transporter 1 ( MDR1 ) P-glycoprotein and the Multidrug Resistance-Associated Protein ( MRP1 ).